These involve adverse neurological outcomes including cerebral palsy, neurodevelopmental delay, vision, and hearing impairment adverse respiratory outcomes including bronchopulmonary dysplasia and a series of adverse outcomes that can affect different systems resulting in lifelong disabilities. 1 Prematurity‐related complications can confer significant neonatal morbidity with potential long‐term implications. 1 This amounts to a total of around 15 million preterm births each year. It represents 5% to 18% of deliveries worldwide, with the impact being higher in low‐ and middle‐income countries. We conclude that urgent collaborative action is required to address the unmet need of developing effective strategies to tackle the challenge of PTB and its complications.Īccording to the long‐standing definition by the World Health Organization, preterm birth (PTB) is delivery before 37 completed weeks of gestation. We provide an overview of more traditional therapies that are currently used or being tested in humans, and we highlight recent advances in preclinical studies introducing novel approaches with therapeutic potential. Here, we discuss therapeutic options that target such key mediators with an aim to prevent, postpone, or treat PTB. Mechanistic studies have identified critical elements of the complex inflammatory molecular pathways involved in PTB. ![]() Even in the absence of infection, inflammation alone can prematurely activate the main components of parturition resulting in uterine contractions, cervical ripening and dilatation, membrane rupture, and subsequent PTB. Over the past few decades, inflammation in gestational tissues has emerged at the forefront of PTB pathophysiology. Despite extensive research in the field, there is currently a paucity of medications available for PTB prevention and treatment. ![]() Preterm birth (PTB defined as delivery before 37 weeks of pregnancy) is the leading cause of morbidity and mortality in infants and children aged <5 years, conferring potentially devastating short‐ and long‐term complications.
0 Comments
Leave a Reply. |